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Withdrawal Symptoms of Cymbalta Duloxetine

- 25th April 2018
Withdrawal Symptoms of Cymbalta Duloxetine

Cymbalta Duloxetine is a prescription drug used for the treatment of anxiety, depression, fibromyalgia, and diabetic neuropathic pain. The medicine works by increasing the presence of the neurotransmitters (norepinephrine and serotonin) in the brain. Cymbalta was approved by the Food and Drug Administration (FDA) in the year 2008, and by 2009 more than 14 million doses of the medication has been dispensed. It was the second drug that was approved by the FDA for treating fibromyalgia. Since its introduction, it has been generally known that sudden discontinuation of the medication, as well as other antidepressant drugs, can cause anti-depressant withdrawal syndrome. Patients who suddenly stop using the medicine are known to experience different side effects and this is why it is highly recommended that individuals do not stop the treatment abruptly. Instead of stopping the usage suddenly, it is advisable that the drug be reduced gradually. It is essential to point out that the severity of side effects is largely dependent on the size of the dosage used by the patient, as well as the duration of usage. Before you decide to stop the treatment, first speak with your physician and agree on the best approach to stopping the medication.

Cymbalta Duloxetine: Withdrawal Syndrome

Stopping Cymbalta abruptly comes with a serious side effect known as Cymbalta Duloxetine withdrawal syndrome. According to the United State Food and Drug Administration Advisory Committee

Feedback on Cymbalta Withdrawal Syndrome, there has been evidence that shows that the sudden discontinuation of the medication can result distress, and injury. The adverse effects of sudden discontinuation of the medication can be severe and continue for a period of time ranging from a couple of weeks to months. So many patients have reported serious and severe effects of discontinuation of the treatment, that it is well worth consulting your physician before you stop your medication. Some of the withdrawal symptoms that can be experienced after sudden discontinuation of Cymbalta include extreme mood swings, suicidal thoughts, insomnia, nightmares, nausea and vomiting, excessive sweating, diarrhea, limb pain, fatigue, headache, agitation, tinnitus, seizures, hypomania, anxiety, involuntary laughing or crying, and hypomania.

Psychological Effects of Withdrawal Symptoms

Patients who abruptly stopped taking Duloxetine may experience some psychological symptoms. In some cases, these psychological symptoms may set in within 24 hours of stopping the medication and can last up to three days or even three weeks. Some of the frequent symptoms of withdrawal include rebound depression, low mood, anxiety, and apathy. Cymbalta strongly impacts on serotonin; it, therefore, takes many days after discontinuation for the body’s natural serotonin system to get back to normal. According to a study published in the Journal of Affective Disorders: December 2005 issue, it was documented that close to 50% of individuals taking Cymbalta Duloxetine for a long period of time experienced some general withdrawal symptoms such as psychiatric disturbances. These psychiatric disturbances include irritability, depression, anxiety, nervousness, and crying.

Sensory and Movement Symptoms

Individuals that stop using Cymbalta may experience episodes of sensory and movement disruptions, such as vertigo, tingling, dizziness, numbness, electric shock sensations, and restlessness. Dizziness has been reported to be the most common symptoms of withdrawal syndrome, occurring in 19% of patients using the medication.

Other Withdrawal Symptoms

There are many other symptoms that a patient can experience during withdrawal. These symptoms include digestive, sleep and physical disturbances. Patients can also experience a headache, flu-like symptoms, and weakness. In addition to these, there is also the likelihood of experiencing gastrointestinal disturbances such as nausea, vomiting, and change in appetite. Sleep disturbances, such as nightmares and insomnia, can also come into play after discontinuation of the medication. In some studies, insomnia was experienced by about 6% of patients who were placed on the medication for a long-term period, while 3% of the patients experienced nightmare episodes.

How to Discontinue Using Cymbalta Duloxetine?

When it comes to stopping the usage of Cymbalta Duloxetine, the prescription information indicates that a gradual reduction on the dosage of the medication instead of sudden discontinuation is recommended. In case unbearable symptoms are experienced during the decrease of the drug, or when the medication is discontinued, it is recommended that the previous dosage be resumed. The medicine can be reduced gradually again at a more low dosage. Although a gradual reduction in the dosage is the best approach to stopping the usage of the medication, it is important to point out that Cymbalta comes in three different doses: 20mg, 30mg, and 60mg. Another issue with the drug is that it is in a capsule form, so breaking it into half is absolutely impossible. On top of that, the capsule cannot be opened to allow reduction of the content. All these make it almost impossible to gradually reduce the dosage of the medication. The next question then will be: What should you do if you want to discontinue using Cymbalta Duloxetine?

If you have been prescribed with Duloxetine and you want to discontinue using this medicine, the first step is to discuss a discontinuation plan with your physician. It is important that your doctor is aware of the severity of Cymbalta Discontinuation Syndrome. You should take time to discuss the different options available for the treatment of the numerous symptoms that may occur in the process of discontinuing the drug. Many doctors have discovered that switching the medication to a different kind of antidepressant that does not come with serious withdrawal symptoms is a great idea. Your health provider will definitely know the best approach to take in helping you discontinue the medication in a systematic manner.


If you are planning on taking the medicine or buy Cymbalta online then it is important to keep in mind the Cymbalta dosage and make sure that you understand the health benefits as well as the risks of withdrawal syndromes. You need to discuss this extensively with your doctor and agree on the best medication to treat your health problems.

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Withdrawal Symptoms of Cymbalta Duloxetine